2019年6月21日下午16点，应红宝石官方网站hbs160邀请，美国科学院院士、德克萨斯大学奥斯汀分校Michael J.Krische教授在化学馆321会议室做了题为“Hydrogen-Mediated C-C Bond Formation”的学术报告。此次报告由化学学院余达刚教授主持，冯小明教授、刘小华教授、刘波教授、高戈教授、Jason Chruma教授、曾小明教授、陈小川教授、郑柯教授、董顺喜教授、付绍敏教授和曹伟地教授等老师及学生参加了此次报告。
在此次报告中，Krische教授首先介绍了碳-碳成键反应在有机合成中的重要意义以及利用传统金属有机试剂参与碳-碳成键反应的发展历程以及局限性，并以此引出他们课题组发展的一系列氢介导的碳-碳成键反应。该类反应是继氢甲酰化反应之后，另一类被系统研究的催化氢化条件下羰基化合物与不饱和烃的碳-碳还原偶联反应。随后，Krische教授进一步讲解了他们课题组发展的基于醇类化合物的氢转移过程，原位产生金属氢物种和羰基化合物，进而实现碳-碳键的高效、高非对映、对映选择性构筑并对反应机理进行了系统深入的研究。利用脱氢/氢转移碳-碳成键策略，他们课题组还完成了一系列多羟基以及聚酮类天然产物的全合成工作，实现了有机合成新方法学和全合成工作的融会贯通。整场报告内容丰富，Krische教授讲解清晰，由浅入深，形象生动地向我们展示了氢介导碳-碳成键反应在有机合成的应用以及在复杂分子全合成中的巨大潜能。在随后的自由提问环节，在座师生与Krische教授进行了深入地讨论交流，大家获益匪浅。报告在全场师生热烈的掌声中落下了帷幕，结束后部分老师与Krische教授进行了合影留念。
Michael J. Krische教授简介：
Prof. Krische got his B.S. from UC Berkeley in 1989 andstudied one year in Helsinki University with Fulbright Fellowship. In 1996 he earned Ph.D. from Stanford University with Prof. Barry M. Trost and then did postdoctoral studiesfor 2.5 years with Prof. Jean-Marie Lehn in Université Louis Pasteur. In 1999 he took the position of Assistant Professor in the University of Texas at Austin and directly promoted to full professor in 2004. He has also been Robert A. Welch Chair in Science University of Texas at Austin since 2007 and Humboldt Senior Research Fellow in Freiburg University since 2009.
His research interests include transition metal catalysis, synthetic methods, total Synthesis and materials science. He has published more than 270 papers in Science, Nat. Chem. and other journals. He has been associate editor of Chem. Commun. and Series Editor for Topics in Current Chemistry since 2011. Prof. Krische is a recipient of many prestigious awards and honors, including Thieme Chemistry Journal Award (2001) , Alfred P. Sloan Research Fellow (2003), ACS Elias J. Corey Award (2007), Presidential Green Chemistry Challenge Award (2007), Novartis Lectureship Award (2008), Tetrahedron Young Investigator Award (2009), Mukaiyama Award (2010), JSPS Research Fellowship (2013), Fellow of the Royal Society of Chemistry (2013), ACS Cope Scholar Award (2013), Royal Society of Chemistry, Pedler Award (2015), Fellow of the American Association for the Advancement of Science (AAAS) (2017).
