Education And Academic Experience：
2016.6～Present Sichuan University, Professor
2014.10～2016.6 University of Michigan, Research Fellow
2012.07～2014.09 The Scripps Research Institute, Research Associate
2007.09～2012.07 Sichuan University, PhD; Asymmetric synthesis
2003.09～2007.07 Sichuan University, Bachelor; Organic chemistry
Publications:
1、Ning Lei, Yanling Shen, Yujun Li, Pan Tao, Zishan Su and Ke Zheng* “Electrochemical Iodoamination of Indoles Using Unactivated Amines” Org. Lett. 2020, DOI: 10.1021/acs.orglett.0c03158 https://doi.org/10.1021/acs.orglett.0c03158
2、Liquan Yang, Zhaoran Liu, Yujun Li, Ning Lei, Yanling Shen, and Ke Zheng* “Electrochemically Enabled C3-Formylation and -Acylation of Indoles with Aldehydes” Org. Lett. 2019, 21, 7702−7707
3、Dong Jing,# Cong Lu,# Zhuo Chen, Songyang Jin, Lijuan Xie, Ziyi Meng, Zhishan Su, Ke Zheng* “Light-Driven Intramolecular C-N Cross-Coupling via a Long-Lived Photoactive Photoisomer Complex” Angew. Chem. Int. Ed. 2019, 58, 14666 –14672.
4、Cong Lu# Zhishan Su,# Dong Jing, Songyang Jin, Lijuan Xie, Liangrui, Li and Ke Zheng*
5、Yujun Li, Qi Yang, Liquan Yang, Ning Lei and Ke Zheng* “A scalable electrochemical dehydrogenative cross-coupling of P(O)H compounds with RSH/ROH” Chem. Commun., 2019, 55, 4981-4984.
6、Angelo Aguilar, # Ke Zheng, # et al. and Shaomeng Wang * “Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction” J. Med. Chem. 2019, 62, 6015−6034.
7、Lijuan Xie, Cong Lu, Dong Jing, Xinrui Ou, and Ke Zheng* “Metal-Free Synthesis of Polycyclic Quinazolinones Enabled by a (NH4)2S2O8-Promoted Intramolecular Oxidative Cyclization” Eur. J. Org. Chem. 2019, 3649−3653.
8、Ke Zheng, Xiaohua Liu, and Xiaoming Feng* “Recent Advances in Metal-Catalyzed Asymmetric 1,4-Conjugate Addition (ACA) of Nonorganometallic Nucleophiles” Chem. Rev. 2018, 118, 7586−7656.
9、Shilin Xu#, Angelo Aguilar#, Tianfeng Xu#, Ke Zheng#, et al. and Shaomeng Wang * “Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein–Protein Interaction” Angew. Chem. Int. Ed. 2018, 57, 1601−1605.
10、Ke Zheng, Chul Min Park, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V. LoGrasso,* and Yangbo Feng* “Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors” ACS Med. Chem. Lett., 2015, 6, 413-418.
11、Yan Yin, Ke Zheng, Nibal Eid, et al, Philip V. LoGrasso,* and Yangbo Feng*“Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors” J. Med. Chem. 2015, 58(4), 1846-1861.
12、Ke Zheng, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V. LoGrasso,* and Yangbo Feng* “Design and Synthesis of Highly Potent and Selective JNK3 Inhibitors: SAR Studies on Aminopyrozal Derivatives” J. Med. Chem. 2014, 57, 10013-10030
13、Ke Zheng, Xiaohua Liu, Song Qin, Mingsheng Xie, Lili Lin, Changwei Hu, and Xiaoming Feng* “Completely OH-Selective FeCl3 Catalyzed Prins Cyclization: Highly Stereoselective Synthesis of 4-OH-Tetrahydropyrans” J. Am. Chem. Soc. 2012, 134, 17564−17573.
14、Ke Zheng, Lili Lin and Xiaoming Feng* “Chiral N,N '-Dioxide-Ni(II) Complex Catalyzed Asymmetric Carbonyl-Ene Reaction of Ethyl Trifluoropyruvate” Acta Chim. Sinica 2012, 70, 1785-1790.
15、Ke Zheng, Chengkai Yin, Xiaohua Liu, and Xiaoming Feng* “Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3-Alkyl-3-Hydroxyoxindoles” Angew. Chem. Int. Ed. 2011, 50, 2573.
16、Ke Zheng, Xiaohua Liu, Jiannan Zhao, Yang Yang, Lili Lin and Xiaoming Feng* “Highly Enantioselective Aza-Ene-Type Reaction Catalyzed by Chiral N,N’-dioxide-nickel(II) Complex” Chem. Commun. 2010, 46, 3771–3773.
17、Ke Zheng, Yang Yang, Jiannan Zhao, Chengkai Yin, Lili Lin, Xiaohua Liu and Xiaoming Feng*. “Magnesium(II)-Catalyzed Asymmetric Ketone-Ene Reaction: Stereocontrolled Access to Enantioenriched Trifluoromethyl-Substituted Compounds” Chem. Eur. J. 2010, 16, 9969.
18、Ke Zheng, Jian Shi, Xiaohua Liu, and Xiaoming Feng*. “Asymmetric Carbonyl-Ene Reaction Catalyzed by Chiral N,N’-Dioxide -Nickel(II) Complex: Remarkably Broad Substrate Scope” J. Am. Chem. Soc. 2008, 130, 15770-15771.
19、Ke Zheng, Bo Qin, Xiaohua Liu and Xiaoming Feng* “Highly Enantioselective Allylation of a-Ketoesters Catalyzed by N,N’-Dioxide-In(III) Complexes” J. Org. Chem. 2007, 72, 8478-8483.
20、Ke Zheng, Bo Qin, Xiaohua Liu and Xiaoming Feng* “Highly Enantioselective Allylation of a-Ketoesters Catalyzed by N,N’-Dioxide-In(III) Complexes” J. Org. Chem. 2007, 72, 8478-8483.
21、Y. Yan, K. Zheng, et al, Y. Feng* and P. LoGrasso*. “Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors” J. Med. Chem. 2015, 58(4), 1846-1861.
22、X. Liu, K. Zheng, and X. M. Feng. “Advancements in the Catalytic Asymmetric Intermolecular Ene-Type Reactions” SYNTHESIS, 2014; 46: 2241-2257
23、J. N. Zhao, K. Zheng, et al and X. M. Feng. “Asymmetric Mukaiyama Aldol Reaction Catalyzed by C2-Symmetric N,N’-Dioxide–Ni(II) Complex” Synlett, 2011, 903-906.
24、P. HaJeung; I. Sarah; H. Pamela; M. Rudy; K. Zheng, et al, Y. Feng and P. LoGrasso. “Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles” Scientific reports 2015, 5, 8047
25、K. Shen, X. H. Liu, K. Zheng, et al and X. M. Feng. “Catalytic Asymmetric Synthesis of 3-(a-Hydroxy-b-carbonyl) Oxindoles by a Sc(III)-Catalyzed Direct Aldol-Type Reaction” Chem. Eur. J. 2010, 16, 3736-3742.
26、J. Shi, M. Wang, L. He, K. Zheng, et al and X. M. Feng. “Enantioselective Michael addition of malononitrile to chalcones catalyzed by a simple quinine-Al(OiPr)3 complex: a simple method for thesynthesis of a chiral 4H-pyran derivative” Chem. Commun. 2009, 45, 4711–4713.
B. Qin, X. H. Liu, J. Shi, K. Zheng, et al and X. M. Feng. “Enantioselective Cyanosilylation of a,a-Dialkoxy Ketones Catalyzed by Proline-Derived in-Situ-Prepared N-Oxide as Bifunctional Organocatalys” J. Org. Chem. 2007, 72, 2374.
